Virtually every disease state associated with chronic or acute thrombosis has had smoking
identified as a risk factor. Further, smoking enhances clot strength as assessed by
thrombelastography. Critically, carbon monoxide, a product of cigarette smoking, has been
demonstrated to enhance plasmatic coagulation in vitro via modulation of a heme
associated with fibrinogen. We hypothesized that plasmatic hypercoagulability and
formation of carboxyhemefibrinogen (COHF) detected with thrombelastographic methods …