Serum ß2-Microglobulin Concentration Correlates with Urinary Concentrations of Type 1 Collagen Cross-Linked N-Telopeptides and Deoxypyridinoline in …
A Al-Awadi, SO Olusi, N Al-Zaid… - Annals of Saudi …, 1998 - annsaudimed.net
A Al-Awadi, SO Olusi, N Al-Zaid, K Prabha
Annals of Saudi Medicine, 1998•annsaudimed.netBACKGROUND: Determination of serum ß2-microglobulin concentration, an invasive
procedure, has been advocated for monitoring patients' response to treatment in rheumatoid
arthritis. The object of this study was to find out if serum ß2-microglobulin concentration
correlated with urinary excretions of type 1 collagen cross-linked N-telopeptides (NTx) and
deoxypyridinoline (Pyrilinks-D) in rheumatoid arthritis (RA). SUBJECTS AND METHODS:
Using chemiluminiscent assay, serum ß2-microglobulin concentrations were estimated in 25 …
procedure, has been advocated for monitoring patients' response to treatment in rheumatoid
arthritis. The object of this study was to find out if serum ß2-microglobulin concentration
correlated with urinary excretions of type 1 collagen cross-linked N-telopeptides (NTx) and
deoxypyridinoline (Pyrilinks-D) in rheumatoid arthritis (RA). SUBJECTS AND METHODS:
Using chemiluminiscent assay, serum ß2-microglobulin concentrations were estimated in 25 …
BACKGROUND
Determination of serum ß2-microglobulin concentration, an invasive procedure, has been advocated for monitoring patients' response to treatment in rheumatoid arthritis. The object of this study was to find out if serum ß2-microglobulin concentration correlated with urinary excretions of type 1 collagen cross-linked N-telopeptides (NTx) and deoxypyridinoline (Pyrilinks-D) in rheumatoid arthritis (RA).
SUBJECTS AND METHODS
Using chemiluminiscent assay, serum ß2-microglobulin concentrations were estimated in 25 female patients with active RA, 25 female with inactive disease, and 25 age-matched healthy female controls. Concentrations of NTx and Pyrilinks-D were also determined by immunoabsorbent assays in spot urine samples from these subject groups.
RESULTS
The serum concentration of ß2-microglobulin in patients with RA (7.45±2.10 mg/L) was significantly higher (P<0.001) than the concentrations in patients with inactive disease (3.33±0.76 mg/L), or than in normal healthy controls (2.74±0.52 mg/L). Similarly, in patients with active RA, the spot urinary concentrations of NTx (123.08±25.53 nmol BCE/mmol creatinine) and Pyrilinks-D (15.08±3.29 nmol/mmol creatinine) were significantly higher (P<0.01) than those in patients with inactive disease (58.42±12.65 nmol BCE/mmol creatinine and 10.10±2.43 nmol/mmol creatinine, respectively). In patients with active RA, serum concentration of ß2-microglobulin correlated positively with spot urinary NTx concentrations (r=0.9910, P=0.0001), and Pyrilinks-D concentration (r=0.6177, P=0.001).
CONCLUSION
In patients with active RA, the spot urinary concentrations of NTx and Pyrilinks-D correlated positively with serum ß2-microglobulin. Therefore, the estimations of these urinary markers may take the place of serum ß2-microglobulin estimation in monitoring the patient's response to treatment in rheumatoid arthritis.
Ann Saudi Med 1998; 18(2): 113-116.
A Al-Awadi, SO Olusi, N Al-Zaid, K Prabha, Serum ß2-Microglobulin Concentration Correlates with Urinary Concentrations of Type 1 Collagen Cross-Linked N-Telopeptides and Deoxypyridinoline in Rheumatoid Arthritis. 1998; 18(2): 113-116
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